Alexandre A . da Silva , Jussara M . do Carmo , Zhen Wang and John E . Hall Obesity Hypertension
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منابع مشابه
The brain melanocortin system, sympathetic control, and obesity hypertension.
Excess weight gain is the most significant, preventable cause of increased blood pressure (BP) in patients with primary (essential) hypertension and increases the risk for cardiovascular and renal diseases. In this review, we discuss the role of the brain melanocortin system in causing increased sympathetic activity in obesity and other forms of hypertension. In addition, we highlight potential...
متن کامل2 3 Brain - Mediated Antidiabetic , Anorexic and Cardiovascular 4 Actions of Leptin Require Melanocortin - 4 Receptor Signaling 5 6 7 8
1 2 3 BRAIN-MEDIATED ANTIDIABETIC, ANOREXIC AND CARDIOVASCULAR 4 ACTIONS OF LEPTIN REQUIRE MELANOCORTIN-4 RECEPTOR SIGNALING 5 6 7 8 Alexandre A. da Silva, Frank T. Spradley, 9 Joey P. Granger, John E. Hall and Jussara M. do Carmo 10 11 Department of Physiology and Biophysics, Mississippi Center for Obesity Research, 12 Cardiovascular-Renal Research Center, University of Mississippi Medical Cen...
متن کاملObesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins.
Excess weight gain contributes to increased blood pressure in most patients with essential hypertension. Although the mechanisms of obesity hypertension are not fully understood, increased renal sodium reabsorption and impaired pressure natriuresis play key roles. Several mechanisms contribute to altered kidney function and hypertension in obesity, including activation of the sympathetic nervou...
متن کاملObesity-induced hypertension: interaction of neurohumoral and renal mechanisms.
Excess weight gain, especially when associated with increased visceral adiposity, is a major cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) hypertension. Increased renal tubular sodium reabsorption impairs pressure natriuresis and plays an important role in initiating obesity hypertension. The mediators of abnormal kidney function and increased blood ...
متن کاملObesity, hypertension, and chronic kidney disease
Obesity is a major risk factor for essential hypertension, diabetes, and other comorbid conditions that contribute to development of chronic kidney disease. Obesity raises blood pressure by increasing renal tubular sodium reabsorption, impairing pressure natriuresis, and causing volume expansion via activation of the sympathetic nervous system and renin-angiotensin-aldosterone system and by phy...
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تاریخ انتشار 2014